I will discuss mechanistic studies of the factors that contribute to t…

I will discuss mechanistic studies of the factors that contribute to these PTM-mediated protein-protein interactions using a combination of high-throughput mechanistic screening, genetic code expansion, and investigation of PTM-isosteres, and how this has led to novel approaches to inhibit them.

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“I will discuss mechanistic studies of the factors that contr…” Marcey Waters. Carolina Quotes, record CQ-E1EBB01AA1. https://carolinaquotes.com/quote/e1ebb01aa1

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Post-translational modiﬁcations, PTMs, in histone proteins, including lysine methylation and acylation, regulate gene expression through recruitment of reader proteins to the nucleosome. Dysregulation of these events is prevalent in a wide range of diseases, such that there is much interest in characterizing these modiﬁcations and their binding partners as well as developing inhibitors for these protein-protein interactions.

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